EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.14.11.29 | L-ascorbic acid can be docked in the binding site of 2-oxoglutarate and may chelate the iron ion, D-ascorbate cannot be docked | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.11.29 | adaptaquin | - |
Homo sapiens | |
1.14.11.29 | ciclopirox | iron chelator | Homo sapiens | |
1.14.11.29 | dimethyloxalyl glycine | mimicks 2-oxoglutarate binding mode | Homo sapiens | |
1.14.11.29 | ethyl 3,4-dihydroxybenzoate | iron chelator that can fit inside the active center | Homo sapiens | |
1.14.11.29 | FG-4592 | mimicks 2-oxoglutarate binding mode | Homo sapiens | |
1.14.11.29 | IOX2 | mimicks 2-oxoglutarate binding mode | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.11.29 | Homo sapiens | Q9GZT9 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.14.11.29 | SH-SY5Y cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.11.29 | L-ascorbate + 2-oxoglutarate + O2 | L-ascorbate is a co-substrate of HIF prolyl hydroxylase PHD that may compete for the binding site of 2-oxoglutarate in the enzyme active center | Homo sapiens | ? + succinate + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.11.29 | Egl nine homolog 1 | - |
Homo sapiens |
1.14.11.29 | EGLN1 | - |
Homo sapiens |
1.14.11.29 | PHD2 | - |
Homo sapiens |